Atopic biomarker changes after exposure to Porphyromonas gingivalis lipopolysaccharide: a small experimental study in Wistar rats

Background: IgE and IgG4 are implicated in atopic development clinically utilized as major biomarkers. Atopic responses following certain pathogens, such Porphyromonas gingivalis (Pg), are currently an area of interest for further research. The aim this study is to measure the level IgE, IgG4, IgG4/IgE ratio periodically after exposure periodontal pathogen Pg lipopolysaccharide (LPS). Methods: We used 16 Wistar rats (Rattus norvegicus) randomly subdivided into four groups: Group 1, injected with placebo; 2, LPS 0.3 µg/mL; 3, 1 4, 3 µg/mL. Sera from all groups were taken retro-orbital plexus before exposure. Results: Levels increased significantly at day-4 day-11. Greater increase rather than contributed rapid decline ratio, detected peripheral blood day-11. Conclusion: Modulation reflected by a decrease that accompanies IgE. Therefore, Pg, keystone during disease, may have tendency disrupt biomarkers.